I do not believe so after reading Genesis 1 and Genesis 4. In Genesis 1, God made man. Genesis 4:16-17 reads, "and Cain went out from the presense of the Lord, and dwelt in the land of Nod, on the east of Eden. And Cain knew his wife; and she conceived, and bare Enoch..."
To this point, Adam and Eve only had Cain and Abel (Genesis 4:1-2). Genesis 4:25 reads, "and Adam knew his wife again; and she bare...Seth: 'for God,' said she, 'hath appointed me another seed instead of Abel, whom Cain slew.'" This verse implies that there were probably none between Abel and Seth.
Genesis 3:3-4 reads, "and Adam lives... and begat a son in his own likeness... and called his name Seth: And the days of Adam after he begat Seth were 800 years and he begat sons and daughters.
I feel that God opened my eyes to see through all these verses that there were more than just Adam and Eve on earth. Adam was who God breathed the breath of life into. How could Cain leave his parents and get married at the time he did if Adam and his wife hadn't born any daughters? There must have been others around.